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45 MinhasG.MorishitaR.ShimamuraM.BansalR.AnandA

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Cobalamin Supplementation There are two primary routes: Parenteral (Injection) 250–1,000 µg subcutaneously once weekly for 4–6 weeks Followed by monthly maintenance if required Oral (Cyanocobalamin or Methylcobalamin) High-dose oral B12 (e.g., 250–500 µg/day) can be effective — even in dogs with malabsorption — due to passive diffusion Methylcobalamin may be more bioavailable, though veterinary research is still emerging 2